Publication Name	World Journal of Hepatology
Manuscript ID	121224
DOI	10.4254/wjh.121224
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Trans-cinnamaldehyde alleviates hepatic steatosis and pyroptosis via SIRT1 activation in acute alcoholic liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Shiuan Tien, Bao-Yi Deng, Xue-Mei Pan, Hong-Sheng Yu, Hao-Xiong Zhou, Yun-Wei Guo and Bin Wu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82070574 National Natural Science Foundation of China No. 82170604
Corresponding Author	Bin Wu, MD, PhD, Professor, Department of Gastroenterology, Alcohol-related Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe District, Guangzhou 510630, Guangdong Province, China. wubin6@mail.sysu.edu.cn
Key Words	Alcoholic liver disease; Trans-cinnamaldehyde; Sirtuin 1; Endoplasmic reticulum stress; Pyroptosis; NOD-like receptor family pyrin domain-containing 3 inflammasome
Core Tip	Trans-cinnamaldehyde (TCA) is effective in ameliorating ethanol-induced acute liver injury. TCA alleviates alcoholic liver disease by promoting sirtuin 1 activity and reducing lipid accumulation, endoplasmic reticulum stress, and pyroptosis.
Citation	Tien S, Deng BY, Pan XM, Yu HS, Zhou HX, Guo YW, Wu B. Trans-cinnamaldehyde alleviates hepatic steatosis and pyroptosis via SIRT1 activation in acute alcoholic liver injury. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.121224
PDF	121224-in-press.pdf

Received	2026-03-21 12:25
Peer-Review Started	2026-03-21 12:38
First Decision by Editorial Office Director	2026-04-03 09:56
Return for Revision	2026-04-03 11:08
Revised	2026-04-26 13:48
Publication Fee Transferred	2026-04-27 08:53
Second Decision by Editor	2026-10-13 06:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-13 09:45
Articles in Press	2026-10-13 09:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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