Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121235
DOI	10.4251/wjgo.121235
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Risk factors for recurrence and metastasis of stage IIIC colorectal cancer: A two-center retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Zheng Ruan, Ling-Xin Zhu, Yuan-Yuan Zeng, Chuan-Hui Lu, Guo-Xian Guan, Jun-Wei Wu and Fan Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81970462 Key Medical and Health Project of Xiamen 3502Z20204001
Corresponding Author	Fan Li, Associate Professor, MD, Department of Colorectal Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Zhenhai Road 55, Xiamen , China, Xiamen 361000, Fujian Province, China. lifan14521@163.com
Key Words	Colorectal cancer; Stage IIIC; Recurrence and metastasis; Metastatic lymph node ratio; Prognostic factors
Core Tip	Patients with stage IIIC colorectal cancer still face a high risk of recurrence and metastasis after undergoing radical surgery. This two-center retrospective study confirmed that preoperative carcinoembryonic antigen ≥ 5.0 μg/L, metastatic lymph node ratio ≥ 0.51, and positive root lymph node metastasis are independent risk factors for recurrence and metastasis. Patients possessing all three risk factors simultaneously constitute a high-risk subgroup. Identifying these key risk factors is conducive to formulating individualized surveillance and treatment strategies.
Citation	Ruan Z, Zhu LX, Zeng YY, Lu CH, Guan GX, Wu JW, Li F. Risk factors for recurrence and metastasis of stage IIIC colorectal cancer: A two-center retrospective cohort study. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.121235
PDF	121235-in-press.pdf

Received	2026-03-21 06:09
Peer-Review Started	2026-03-21 11:37
First Decision by Editorial Office Director	2026-04-04 02:07
Return for Revision	2026-04-04 02:07
Revised	2026-04-28 14:52
Publication Fee Transferred	2026-05-13 08:42
Second Decision by Editor	2026-06-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 06:53
Articles in Press	2026-06-15 06:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com