Publication Name	World Journal of Gastroenterology
Manuscript ID	121244
DOI	10.3748/wjg.121244
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Wenyang Jiedu Huayu Formula targets succinate metabolism to alleviate acute-on-chronic liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Zhou, Xiao-Ling Tian, Yi-Fang Zhou, Zhuo-Yu Zhou, Nian-Hua Tan and Bin Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82575008 Chinese Medicine Advantageous Disease (Clinical Evidence-Based Capacity Enhancement) Project of the National Administration of Traditional Chinese Medicine czxm-kyb-2025001 Hunan Provincial Natural Science Foundation of China 2026JJ30167, 2026JJ50326 University-Hospital Joint Fund Project of Hunan University of Chinese Medicine 2024XYLH343 Hunan Provincial Postgraduate Research Innovation Project 2024CX018
Corresponding Author	Bin Chen, Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. chenbin0410@126.com
Key Words	Acute-on-chronic liver failure; Wenyang Jiedu Huayu Formula; Succinate metabolism; Succinate dehydrogenase; Hypoxia-inducible factor-1α; Macrophages; Metabolic reprogramming
Core Tip	This study demonstrated that Wenyang Jiedu Huayu Formula (WYJD) ameliorated acute-on-chronic liver failure by targeting succinate metabolism. WYJD acts partly through succinate dehydrogenase to clear accumulated succinate and suppress hypoxia-inducible factor-1α signaling, thereby correcting energy metabolic disturbances and attenuating macrophage-mediated inflammation. These findings suggested that succinate metabolism can be a potential therapeutic target in acute-on-chronic liver failure, and the study provided mechanistic insights supporting the clinical application of WYJD from a metabolic-immune perspective.
Citation	Zhou J, Tian XL, Zhou YF, Zhou ZY, Tan NH, Chen B. Wenyang Jiedu Huayu Formula targets succinate metabolism to alleviate acute-on-chronic liver failure. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121244
PDF	121244-in-press.pdf

Received	2026-03-20 13:41
Peer-Review Started	2026-03-20 13:41
First Decision by Editorial Office Director	2026-04-10 10:15
Return for Revision	2026-04-10 10:15
Revised	2026-04-25 09:23
Publication Fee Transferred	2026-04-29 05:40
Second Decision by Editor	2026-06-30 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-30 07:44
Articles in Press	2026-06-30 07:44
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ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	This study demonstrated that Wenyang Jiedu Huayu Formula (WYJD) ameliorated acute-on-chronic liver failure by targeting succinate metabolism. WYJD acts partly through succinate dehydrogenase to clear accumulated succinate and suppress hypoxia-inducible factor-1α signaling, thereby correcting energy metabolic disturbances and attenuating macrophage-mediated inflammation. These findings suggested that succinate metabolism can be a potential therapeutic target in acute-on-chronic liver failure, and the study provided mechanistic insights supporting the clinical application of WYJD from a metabolic-immune perspective.
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