Publication Name	World Journal of Clinical Oncology
Manuscript ID	121262
DOI	10.5306/wjco.121262
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Whole-exome sequencing identification of the risk variants in a middle-aged adult with intracranial Ewing’s sarcoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Cheng, Xiao Yu, Zhao-Na Song, Ming-Jun Li, Xiang-Rong Zhao, Xiao-Dong Jia, Zhen Liu, Zhen Yu and Feng-Yan Zhang
Funding Agency and Grant Number
Corresponding Author	Feng-Yan Zhang, Department of Radiotherapy, Liaocheng People’s hospital, Liaocheng 252000, Shandong, China, Liaocheng 252000, Shandong Province, China. a18653610708@126.com
Key Words	Ewing’s sarcoma; Intracranial tumor; Whole-exome sequencing; Variants; Case report
Core Tip	Ewing’s sarcoma (EWS) and Ewing’s-like sarcoma represent uncommon and extremely aggressive round cell mesenchymal malignancies. Here, we describe a case of a 51-year-old man with a confirmed diagnosis of EWS. The article introduces the diagnosis and treatment process. The findings from whole-exome sequencing highlighted the plausible impact of neurofibromin 1 and secreted protein acidic and rich in cysteine on EWS progression.
Citation	Cheng Y, Yu X, Song ZN, Li MJ, Zhao XR, Jia XD, Liu Z, Yu Z, Zhang FY. Whole-exome sequencing identification of the risk variants in a middle-aged adult with intracranial Ewing’s sarcoma: A case report. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.121262
PDF	121262-in-press.pdf

Received	2026-03-23 03:40
Peer-Review Started	2026-03-23 03:43
First Decision by Editorial Office Director	2026-04-30 07:28
Return for Revision	2026-04-30 07:28
Revised	2026-05-19 02:32
Publication Fee Transferred	2026-05-22 01:13
Second Decision by Editor	2026-06-15 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 09:14
Articles in Press	2026-06-15 09:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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