Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	121263
Country	Bahrain

Category	Genetics & Heredity
Manuscript Type	Retrospective Cohort Study
Article Title	UGT1A1-related disorders in Bahrain: A genetic and clinical overview of Crigler-Najjar and Gilbert syndromes
Manuscript Source	Unsolicited Manuscript
All Author List	Hasan M Isa, Fatema A Abdulaal, Maryam Y Busehail, Maryam H Kamal, Hawra A Alaswad, Fatima Y Alshaikh, Aysha A Aljassmi and Anfal J Hijris
Funding Agency and Grant Number
Corresponding Author	Hasan M Isa, Associate Professor, Consultant, Principal Investigator, Senior Researcher, Department of Pediatrics, College of Medicine and Medical Sciences, Arabian Gulf University, 2904 Al Salmaniya Area, Manama 26671, Bahrain. halfaraj@hotmail.com
Key Words	Indirect hyperbilirubinemia; UGT1A1-related disorders; Crigler-Najjar syndrome; Gilbert syndrome; Bahrain
Core Tip	This first study from Bahrain demonstrated that UGT1A1-related disorders represent important causes of persistent unconjugated hyperbilirubinemia, affecting 2.2 per 100000 individuals. Gilbert syndrome (GS) was the most common phenotype, followed by Crigler–Najjar syndrome (CNS) type I and type II. Early genetic testing is crucial for diagnosis, particularly in patients with parental consanguinity and those with associated hematological disorders, mainly glucose-6-phosphate dehydrogenase deficiency. Homozygous (TA)7/7 was the most common variant. CNS-I requires lifelong phototherapy or liver transplantation, whereas CNS-II is treated with phenobarbital; however, treatment adherence remains challenging. No treatment is required for GS.
Citation	Isa HM, Abdulaal FA, Busehail MY, Kamal MH, Alaswad HA, Alshaikh FY, Aljassmi AA, Hijris AJ. UGT1A1-related disorders in Bahrain: A genetic and clinical overview of Crigler-Najjar and Gilbert syndromes. World J Clin Pediatr 2026; In press

Received	2026-03-23 00:55
Peer-Review Started	2026-03-23 00:57
First Decision by Editorial Office Director	2026-04-04 02:37
Return for Revision	2026-04-04 02:37
Revised	2026-04-17 16:26
Publication Fee Transferred	2026-04-20 08:24
Second Decision by Editor	2026-05-19 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 08:16
Articles in Press	2026-05-19 08:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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