Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	121264
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Fructose malabsorption associated with functional abdominal bloating: Case-control study
Manuscript Source	Invited Manuscript
All Author List	Arivarasan Kulandaivelu, Venkatesh Vaithiyam, Kartik Mehta, Ravi Teja Reddy, Aarushi Ahuja, Nikhil Sirohi, Ujjwal Sonika, Ashok Dalal, Ajay Kumar, Amarender Singh Puri and Sanjeev Sachdeva
Funding Agency and Grant Number
Corresponding Author	Sanjeev Sachdeva, Director, Head, Professor, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, JL Nehru Marg, New Delhi 110002, Delhi, India. sanjeevgastro@rediffmail.com
Key Words	Fructose malabsorption; Fructose intolerance; Functional bloating; Small intestinal bacterial overgrowth; Methane producer
Core Tip	Fructose malabsorption (FM) is increasingly recognised as a contributor to functional gastrointestinal symptoms. In this case-control study, FM was significantly more common in patients with functional abdominal bloating than in healthy controls (29% vs 3%). A subset of patients with functional bloating who tested negative for the fructose hydrogen breath test (FHBT) had symptoms during the FHBT, suggesting a mechanism beyond fructose malabsorption, such as visceral hypersensitivity, in the pathogenesis of functional bloating. Female sex was identified as an independent predictor. These findings suggest that FM may be an important, potentially modifiable factor in patients presenting with functional bloating.
Citation	Kulandaivelu A, Vaithiyam V, Mehta K, Reddy RT, Ahuja A, Sirohi N, Sonika U, Dalal A, Kumar A, Puri AS, Sachdeva S. Fructose malabsorption associated with functional abdominal bloating: Case-control study. World J Gastrointest Pharmacol Ther 2026; In press

Received	2026-03-22 03:22
Peer-Review Started	2026-03-22 03:23
First Decision by Editorial Office Director	2026-04-15 09:00
Return for Revision	2026-04-15 09:00
Revised	2026-04-24 19:32
Publication Fee Transferred
Second Decision by Editor	2026-05-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 08:36
Articles in Press	2026-05-11 08:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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