Publication Name	World Journal of Gastroenterology
Manuscript ID	121267
DOI	10.3748/wjg.121267
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Jing, Lei Qin, Xiao-Han Zhang, Fei Pan, Rong-Rong Ren, Yan Li, Yan Zhang, Li-Hua Peng, Zi-Kai Wang and Xiu-Li Zhang
Funding Agency and Grant Number
Corresponding Author	Xiu-Li Zhang, Chief, MD, PhD, Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. zhangxl70@126.com
Key Words	Colorectal tumors; Colorectal cancer; Advanced adenoma; Fecal immunochemical test; Fecal calprotectin; Diagnostic efficiency
Core Tip	Fecal calprotectin is a calcium-containing antimicrobial protein complex. Currently, it is primarily used in clinical practice for the diagnosis and monitoring of inflammatory bowel disease; however, its diagnostic value in colorectal tumors remains to be established. This paper draws a preliminary conclusion that fecal calprotectin can serve as a reliable biomarker for colorectal cancer. When combined with the fecal high-sensitivity quantitative immunochemical test, calprotectin increases the sensitivity for diagnosing colorectal cancer to 87.5%, raises the negative predictive value to 82.8%, and achieves an area under the receiver operating characteristic curve of 0.866. The combination of two biomarkers enhances the diagnostic efficacy for colorectal tumors.
Citation	Jing W, Qin L, Zhang XH, Pan F, Ren RR, Li Y, Zhang Y, Peng LH, Wang ZK, Zhang XL. Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121267
PDF	121267-in-press.pdf

Received	2026-03-20 13:30
Peer-Review Started	2026-03-20 13:32
First Decision by Editorial Office Director	2026-05-08 10:05
Return for Revision	2026-05-08 10:05
Revised	2026-06-02 12:21
Publication Fee Transferred	2026-06-08 05:55
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 06:51
Articles in Press	2026-06-22 06:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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