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Articles in Press
7/15/2026 3:45:52 AM | Browse: 3 | Download: 0
| Category |
Psychology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Evolocumab intensive lipid-lowering therapy on prognosis of post-cerebral infarction depression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Yang, Hong-Yan Song, Meng-Jun Zhang, Shu-Gen Wang and Wan-Gen Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Key Research and Development Program of Cangzhou |
23244102156 |
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| Corresponding Author |
Yue Yang, Department of Pharmacy, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou 061000, Hebei Province, China. 825994864@qq.com |
| Key Words |
Post-cerebral infarction depression; Evolocumab; Intensive lipid-lowering therapy; Prognosis; Proprotein convertase subtilisin/kexin type 9; Neuroinflammation; Functional recovery |
| Core Tip |
This retrospective study shows that evolocumab lipid-lowering therapy greatly ameliorates the multi-dimensional prognosis in patients with post-cerebral infarction depression. The remission rates for depression nearly doubled (58.3% vs 31.9%) associated with concurrent improvements in cognition, functional independence, and rehospitalization. This parallel reduction in inflammatory markers with proprotein convertase subtilisin/kexin type 9 further supports a neuroinflammation-mediated mechanism. These results delineate evolocumab as an approach with dual therapeutic implications mitigating cardiovascular risk and neuropsychiatric sequelae in patients post-cerebral infarction. |
| Citation |
Yang Y, Song HY, Zhang MJ, Wang SG, Liu WG. Evolocumab intensive lipid-lowering therapy on prognosis of post-cerebral infarction depression. World J Psychiatry 2026; In press
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Received |
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2026-04-22 10:07 |
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Peer-Review Started |
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2026-04-22 10:07 |
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First Decision by Editorial Office Director |
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2026-05-20 08:16 |
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Return for Revision |
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2026-05-20 08:16 |
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Revised |
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2026-06-10 09:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-07-15 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-15 03:45 |
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Articles in Press |
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2026-07-15 03:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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