Publication Name	World Journal of Gastroenterology
Manuscript ID	121284
DOI	10.3748/wjg.121284
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-You Bu, Xin Li, Tian-Yu Zhou, Jia-He Gu, Jia-Ning Zhu, Jia-Lu Li, Bin-Bin Zeng, Wei-Bing Zu and Dong Tang
Funding Agency and Grant Number
Corresponding Author	Dong Tang, MD, PhD, Department of General Surgery, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225000, Jiangsu Province, China. 83392785@qq.com
Key Words	Intestinal barrier; Intestinal diseases; Mechanosensation; Piezo channel; Targeted therapy
Core Tip	Piezo mechanical sensitive channel is the core mechanical transduction hub for maintaining intestinal homeostasis, which can convert mechanical force into biological signals. They regulate a complex network encompassing epithelial renewal, barrier integrity, immune response and gastrointestinal dynamics. Piezo channel dysfunction can directly drive the development of inflammatory bowel disease, irritable bowel syndrome and colon cancer. Therefore, the pharmacological regulation of the Piezo channels by using specific drugs such as the agonist Yoda1 or the inhibitor grammostola spatulata mechanosensitive channel toxin 4 can provide a promising treatment strategy for the intestinal diseases.
Citation	Bu YY, Li X, Zhou TY, Gu JH, Zhu JN, Li JL, Zeng BB, Zu WB, Tang D. Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121284
PDF	121284-in-press.pdf

Received	2026-03-23 03:26
Peer-Review Started	2026-03-23 03:27
First Decision by Editorial Office Director	2026-04-23 09:49
Return for Revision	2026-04-23 09:49
Revised	2026-05-11 08:31
Publication Fee Transferred	2026-05-20 08:09
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 06:46
Articles in Press	2026-06-22 06:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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