Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	121285
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Mechanisms and treatment of metabolic dysfunction-associated fatty liver disease after liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Rong Liu, Liu Zhao, Qing-Hui Niu, Jin-Zhen Cai and Han-Yun Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82300665
Corresponding Author	Liu Zhao, Department of Liver Center, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Laoshan District, Qingdao 266000, Shandong Province, China. zhaoliuqdfy@163.com
Key Words	Metabolism dysfunction-associated fatty liver disease; Diabetes; Hypertension; Hyperlipidemia; Immunosuppressants
Core Tip	Metabolism dysfunction-associated fatty liver disease has become a prevalent complication following liver transplantation, appearing as either de novo or recurrent disease. The long-term use of immunosuppressants, specifically glucocorticoids, calcineurin inhibitors, and mammalian target of rapamycin inhibitors, serves as a primary driver of metabolic syndrome by disrupting glucose and lipid homeostasis. In this review, we delineate the synergistic mechanisms of drug-induced insulin resistance, hypertension, and dyslipidemia that promote hepatic steatosis. Management requires a multi-faceted strategy integrating lifestyle modifications, targeted metabolic pharmacotherapy and the optimization of immunosuppressive regimens to balance graft protection with metabolic health.
Citation	Liu JR, Zhao L, Niu QH, Cai JZ, Liu HY. Mechanisms and treatment of metabolic dysfunction-associated fatty liver disease after liver transplantation. World J Gastrointest Surg 2026; In press

Received	2026-03-23 03:27
Peer-Review Started	2026-03-23 03:27
First Decision by Editorial Office Director	2026-04-08 09:04
Return for Revision	2026-04-10 00:47
Revised	2026-04-23 14:58
Publication Fee Transferred	2026-04-25 05:58
Second Decision by Editor	2026-05-19 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 08:54
Articles in Press	2026-05-19 08:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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