Publication Name	World Journal of Gastroenterology
Manuscript ID	121290
DOI	10.3748/wjg.121290
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Hyoung Il Choi, Jung Rock Moon, Sun Hwa Lee and Jae Myung Cha
Funding Agency and Grant Number	Funding Agency Grant Number BongHwa Scholarship Foundation to the Korean Association for the Study of Intestinal Diseases for 2024
Corresponding Author	Jae Myung Cha, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul 05278, South Korea. drcha@khu.ac.kr
Key Words	Biological products; Crohn’s disease; Inflammatory bowel disease; Ulcerative colitis; Treatment pathway
Core Tip	This nationwide Korean study demonstrates that advanced therapy use for inflammatory bowel disease shows distinct patterns between Crohn’s disease and ulcerative colitis. Anti-tumor necrosis factor agents, particularly infliximab, are the most common first-line treatments, with earlier initiation and longer persistence in Crohn’s disease. In contrast, vedolizumab is more frequently used for ulcerative colitis, and ustekinumab more commonly used for Crohn’s disease. Overall, treatment sequencing and durability differed significantly according to disease subtype, highlighting the importance of tailored, disease-specific therapeutic strategies in real-world clinical practice.
Citation	Choi HI, Moon JR, Lee SH, Cha JM. Advanced therapies in patients with inflammatory bowel disease: A nationwide population-based cohort study. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121290
PDF	121290-in-press.pdf

Received	2026-03-23 00:48
Peer-Review Started	2026-03-23 00:48
First Decision by Editorial Office Director	2026-05-20 09:21
Return for Revision	2026-05-20 09:21
Revised	2026-06-12 23:52
Publication Fee Transferred
Second Decision by Editor	2026-07-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 08:35
Articles in Press	2026-07-02 08:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com