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Articles in Press
6/15/2026 7:24:19 AM | Browse: 9 | Download: 4
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Crosstalk between neutrophils and hepatic stellate cells in liver injury and repair: Mechanisms and implications
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Jie Lian, Ming-Yang Li, Li Wang, Yu-Wen Gao, Dan Zhu and Wen-Liang Lyu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| High Level Chinese Medical Hospital Promotion Project |
HLCMHPP2023086 |
| Fundamental Research Funds for the Central Public Welfare Research Institutes |
ZZ19-XRZ-045 |
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| Corresponding Author |
Wen-Liang Lyu, PhD, Professor, Department of Infectious Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China. lvwenliang2892@gamyy.cn |
| Key Words |
Liver injury; Liver repair; Neutrophils; Hepatic stellate cells; Cell crosstalk |
| Core Tip |
Crosstalk between neutrophils and hepatic stellate cells is a crucial regulatory axis that determines whether liver injury resolves or progresses to fibrosis. This interaction is highly context- and stage-dependent. During acute injury, it triggers transient reparative signaling; however, in diseases such as metabolic dysfunction-associated steatohepatitis, liver cirrhosis, and hepatocellular carcinoma, it promotes persistent pathological activation. Targeting specific nodes within this crosstalk (e.g., neutrophil extracellular traps, NOD-like receptor family pyrin domain containing 3, transforming growth factor-β) enables a precision-remodeling strategy, offering stage-specific anti-fibrotic interventions while preserving essential immune repair functions. |
| Citation |
Lian YJ, Li MY, Wang L, Gao YW, Zhu D, Lyu WL. Crosstalk between neutrophils and hepatic stellate cells in liver injury and repair: Mechanisms and implications. World J Gastroenterol 2026; In press
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| PDF |
121310-in-press.pdf
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Received |
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2026-03-23 03:24 |
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Peer-Review Started |
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2026-03-23 03:25 |
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First Decision by Editorial Office Director |
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2026-04-10 10:16 |
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Return for Revision |
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2026-04-10 10:16 |
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Revised |
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2026-04-30 15:03 |
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Publication Fee Transferred |
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2026-05-09 06:22 |
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Second Decision by Editor |
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2026-06-15 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-15 07:24 |
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Articles in Press |
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2026-06-15 07:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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