Publication Name	World Journal of Diabetes
Manuscript ID	121312
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Effects of hyperglycemia on the bone microenvironment in diabetic osteoporosis
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Li, Wei Wei, Yan-Long Zhang and Xi-Xu Zhang
Funding Agency and Grant Number
Corresponding Author	Xi-Xu Zhang, Professor, Department of Endocrinology, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 60 Huanghe North Street, Shenyang 261000, Liaoning Province, China. 13287683505@163.com
Key Words	Diabetic osteoporosis; Bone microenvironment; Hyperglycemia; Oxidative stress; Inflammation
Core Tip	Diabetic osteoporosis (DOP) poses a major health challenge, elevating fracture risk. Chronic hyperglycemia is central to DOP pathogenesis, instigating oxidative stress via excessive reactive oxygen species and advanced glycation end products, plus inflammation involving the nuclear factor-kappa B signaling pathway within the bone microenvironment. This disrupts bone remodeling. Understanding these molecular mechanisms is crucial for developing innovative prevention and treatment strategies for DOP.
Citation	Li B, Wei W, Zhang YL, Zhang XX. Effects of hyperglycemia on the bone microenvironment in diabetic osteoporosis. World J Diabetes 2026; In press

Received	2026-03-23 00:31
Peer-Review Started	2026-03-24 06:03
First Decision by Editorial Office Director	2026-04-15 07:53
Return for Revision	2026-04-15 07:53
Revised	2026-04-17 13:14
Publication Fee Transferred	2026-04-20 13:03
Second Decision by Editor	2026-05-14 02:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-21 08:42
Articles in Press	2026-05-21 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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