Publication Name	World Journal of Psychiatry
Manuscript ID	121314
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Glycemic indicators influence hypercoagulability via multisystem pathways in psychiatric inpatients: Structural equation modeling
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Wei, Hong-Ying Du, Qian He, Shao-Shen Jia, Fu-Gang Luo and Yi-Chao Wang
Funding Agency and Grant Number
Corresponding Author	Yi-Chao Wang, MD, Psychiatric Emergency Department (PED) and Psychiatric Intensive Care Units (PICU), Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, No. 305, Tianmu South Road, Hangzhou City, Hangzhou 310000, Zhejiang Province, China. wangyichao@hz7hospital.com
Key Words	Major psychiatric disorders; Fasting plasma glucose; Fructosamine; Hemoglobin A1c; D-dimer; Structural equation modeling
Core Tip	This study innovatively applies structural equation modeling to reveal how glycemic indicators across different time scales influence hypercoagulability, marked by D-dimer, in psychiatric inpatients. Fasting plasma glucose actively promotes hypercoagulability via inflammatory pathways. Conversely, fructosamine robustly protects against it, acting as a surrogate for nutritional and anticoagulant reserves rather than mere glycemic control. Glycated hemoglobin showed negligible direct acute effects. These findings shift the paradigm of psychiatric coagulopathy from a simplistic metabolic complication to a multi-system cascade, highlighting the necessity of integrated metabolic, inflammatory, and nutritional clinical assessments.
Citation	Wei J, Du HY, He Q, Jia SS, Luo FG, Wang YC. Glycemic indicators influence hypercoagulability via multisystem pathways in psychiatric inpatients: Structural equation modeling. World J Psychiatry 2026; In press

Received	2026-03-23 06:01
Peer-Review Started	2026-03-23 06:04
First Decision by Editorial Office Director	2026-05-15 10:39
Return for Revision	2026-05-15 10:39
Revised	2026-05-29 15:31
Publication Fee Transferred	2026-06-04 14:44
Second Decision by Editor	2026-07-01 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-01 03:08
Articles in Press	2026-07-01 03:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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