Publication Name	World Journal of Gastroenterology
Manuscript ID	121333
DOI	10.3748/wjg.121333
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Long-term comparative effectiveness of first-line infliximab vs corticosteroids in ulcerative colitis: Remission and colectomy risk
Manuscript Source	Unsolicited Manuscript
All Author List	Hossam M Elsaadany, Basem Abd El-Hamid, Emad A Elewesy, Mohamed I Mansour, Wafaa M Abdelghany, Maged A H Shoukeer, Mohamed Khalaf, Sameh M Eid and Mohammed T Almaghraby
Funding Agency and Grant Number
Corresponding Author	Hossam M Elsaadany, Consultant, MD, Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Al-Bahr Street, Third District, New Damietta 34517, Damietta, Egypt. dr.saadany2019@gmail.com
Key Words	Ulcerative colitis; Infliximab; Corticosteroids; Biologic therapy; Long-term outcomes; Colectomy
Core Tip	This prospective multicenter study compared first-line infliximab with intravenous corticosteroids in patients with moderate-to-severe ulcerative colitis. Early use of infliximab was associated with higher rates of sustained clinical, endoscopic, and histologic remission, along with a significantly reduced risk of colectomy over long-term follow-up. In contrast, intravenous corticosteroids was linked to lower remission durability and higher rates of severe adverse events. These findings support a shift toward early biologic therapy in selected high-risk patients to improve long-term outcomes and reduce steroid-related complications.
Citation	Elsaadany HM, Abd El-Hamid B, Elewesy EA, Mansour MI, Abdelghany WM, Shoukeer MAH, Khalaf M, Eid SM, Almaghraby MT. Long-term comparative effectiveness of first-line infliximab vs corticosteroids in ulcerative colitis: Remission and colectomy risk. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121333
PDF	121333-in-press.pdf

Received	2026-03-23 02:09
Peer-Review Started	2026-03-23 02:10
First Decision by Editorial Office Director	2026-04-28 01:54
Return for Revision	2026-04-28 01:54
Revised	2026-05-09 23:32
Publication Fee Transferred	2026-05-13 20:26
Second Decision by Editor	2026-06-17 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-17 07:44
Articles in Press	2026-06-17 07:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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