Publication Name	World Journal of Orthopedics
Manuscript ID	121358
Country	China

Category	Orthopedics
Manuscript Type	Observational Study
Article Title	Effects of hydrogen inhalation duration on symptom relief in elderly patients with knee osteoarthritis: A pilot study
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Hui Wang, Yu-Ru Li, Lei Han, Hong-Qian Wang, Shu-Feng Jia, Xing-Chen Liu, Hao Wu, Fan Wu and Bao-Guo Wang
Funding Agency and Grant Number	Funding Agency Grant Number Capital’s Funds for Health Improvement and Research CFH2024-3-8011
Corresponding Author	Bao-Guo Wang, Chief Physician, MD, Professor, Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, No. 36 Courtyard, Dongba Middle Road, Chaoyang District, Beijing 100018, China. wangbg@ccmu.edu.cn
Key Words	Hydrogen; Elderly; Osteoarthritis; Dose-response relationship; Non-pharmacological management
Core Tip	This pilot study is the first to demonstrate a dose-response relationship between cumulative hydrogen inhalation duration and symptom relief in elderly patients with knee osteoarthritis. Long-term inhalation (over 30 cumulative hours) provided significantly greater improvements in pain, stiffness, and physical function than short-term inhalation. The therapeutic benefit followed a logarithmic curve, plateauing after approximately 114 cumulative hours, suggesting a potential saturation point for clinical efficacy.
Citation	Wang CH, Li YR, Han L, Wang HQ, Jia SF, Liu XC, Wu H, Wu F, Wang BG. Effects of hydrogen inhalation duration on symptom relief in elderly patients with knee osteoarthritis: A pilot study. World J Orthop 2026; In press

Received	2026-03-24 03:06
Peer-Review Started	2026-03-24 03:07
First Decision by Editorial Office Director	2026-04-03 02:51
Return for Revision	2026-04-03 02:51
Revised	2026-04-18 11:29
Publication Fee Transferred	2026-04-22 10:24
Second Decision by Editor	2026-05-13 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-13 04:32
Articles in Press	2026-05-13 04:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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