Publication Name	World Journal of Meta-Analysis
Manuscript ID	121388
DOI	10.13105/wjma.121388
Country	India

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Systematic Reviews
Article Title	Gut microbiota axis in periodontitis: A systematic review and meta-analysis of inflammatory and microbial interactions
Manuscript Source	Invited Manuscript
All Author List	Neelam Das
Funding Agency and Grant Number
Corresponding Author	Neelam Das, Associate Professor, Department of Periodontology, Sri Sai College of Dental Surgery, 1-2-64/1 and 2, Kothrepally, Alampally, Vikarabad 501102, Telangana, India. dasneelam423@gmail.com
Key Words	Periodontitis; Gut microbiota; Dysbiosis; Systemic inflammation; Microbial diversity; Host immune response; Systematic review; Meta-analysis
Core Tip	This updated systematic review and meta-analysis up to January 2026 shows that gut microbiota dysbiosis is associated with increased periodontal disease severity. Reduced microbial diversity, altered Firmicutes to Bacteroidetes ratio, enrichment of pro inflammatory taxa, and depletion of short chain fatty acid producing bacteria were consistently observed. These changes correlated with elevated systemic inflammatory markers and worse periodontal clinical parameters. The findings support the role of the gut microbiota axis in periodontal disease and highlight its potential relevance for future diagnostic and therapeutic strategies.
Citation	Das N. Gut microbiota axis in periodontitis: A systematic review and meta-analysis of inflammatory and microbial interactions. World J Meta-Anal 2026; In press DOI: https://doi.org/10.13105/wjma.121388
PDF	121388-in-press.pdf

Received	2026-03-24 03:34
Peer-Review Started	2026-03-24 03:35
First Decision by Editorial Office Director	2026-04-30 08:52
Return for Revision	2026-04-30 14:56
Revised	2026-05-12 16:33
Publication Fee Transferred
Second Decision by Editor	2026-06-23 02:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-23 07:09
Articles in Press	2026-06-23 07:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2308-3840 (online)
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