Publication Name	World Journal of Meta-Analysis
Manuscript ID	121391
Country	Kenya

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Molecular targets of ivermectin as a potential repurposed drug in cancer therapy: A scoping review
Manuscript Source	Unsolicited Manuscript
All Author List	Roy Olunga, Walter Jaoko, Reinhard Kipkoech, Gloria Natalia, Ruth J Tai, Lydia Mutanu, Moses Jengo, Faith W Mwangi, Olivia Ayuma and Udochukwu G Anosike
Funding Agency and Grant Number
Corresponding Author	Roy Olunga, Department of Clinical Medicine and Therapeutics, University of Nairobi, Ngong Road, Nairobi 00100, Nairobi City, Kenya. royolunga71@gmail.com
Key Words	Ivermectin; Cancer; Ivermectin-drug interactions; Drug repurposing; Molecular targets
Core Tip	Ivermectin shows promise as a repurposed anticancer agent by targeting multiple molecular pathways, including inhibition of Wnt/β-catenin signaling, modulation of p21-activated kinase 1 activity, and induction of mitochondrial dysfunction. Its ability to induce apoptosis, suppress tumor growth, and overcome drug resistance highlights its therapeutic potential across diverse cancer types. Available clinical evidence is preliminary and requires rigorous clinical validation to establish safety, efficacy, and optimal dosing in oncology. Ivermectin’s multitargeted mechanisms make it a possible candidate for cancer therapy, but translation into clinical practice demands cautious, evidence-based evaluation through well-designed clinical trials.
Citation	Olunga R, Jaoko W, Kipkoech R, Natalia G, Tai RJ, Mutanu L, Jengo M, Mwangi FW, Ayuma O, Anosike UG. Molecular targets of ivermectin as a potential repurposed drug in cancer therapy: A scoping review. World J Meta-Anal 2026; In press

Received	2026-03-24 01:57
Peer-Review Started	2026-03-24 01:57
First Decision by Editorial Office Director	2026-04-03 04:59
Return for Revision	2026-04-03 07:23
Revised	2026-04-13 19:05
Publication Fee Transferred
Second Decision by Editor	2026-06-01 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-01 09:55
Articles in Press	2026-06-01 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2308-3840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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