Publication Name	World Journal of Psychiatry
Manuscript ID	121407
DOI	10.5498/wjp.121407
Country	China

Category	Psychology
Manuscript Type	Retrospective Study
Article Title	Serum NfL and GFAP levels and their association with anxiety-depression in Alzheimer’s disease patients: A clinical retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Guang-Wen Xu, Xiao-Ling Zhu and Chang-Hao Yin
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Heilongjiang Province No. ZL2024H014
Corresponding Author	Chang-Hao Yin, Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical University, No. 5 Tongxiang Road, Aimin District, Mudanjiang 157011, Heilongjiang Province, China. yinchanghao1234@163.com
Key Words	Alzheimer’s disease; Anxiety; Depression; Neurofilament light chain; Glial fibrillary acidic protein; Biomarkers; Age stratification; Retrospective analysis
Core Tip	Anxiety and depression are common neuropsychiatric disorders that negatively influence prognosis and quality of life in patients with Alzheimer’s disease. Results from this study show that the combination of serum neuroaxonal damage marker and astrocytic activation marker, not the single markers, have improved prognostic value for anxiety and depression. Age-stratified analysis provides further evidence of a strong age-dependent gradient in anxiety-depression prevalence These findings highlight the role of thorough biomarker assessment in combination with age-related risk stratification in everyday clinical practice to identify and treat at-risk patients better and earlier for Alzheimer’s disease.
Citation	Xu GW, Zhu XL, Yin CH. Serum NfL and GFAP levels and their association with anxiety-depression in Alzheimer’s disease patients: A clinical retrospective study. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.121407

Received	2026-03-24 03:14
Peer-Review Started	2026-03-24 03:15
First Decision by Editorial Office Director	2026-04-10 07:43
Return for Revision	2026-04-10 07:43
Revised	2026-04-20 09:09
Publication Fee Transferred	2026-04-21 14:20
Second Decision by Editor	2026-06-01 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-03 06:21
Articles in Press	2026-06-03 06:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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