Publication Name	World Journal of Hepatology
Manuscript ID	121423
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Ya Zhou, Rong-Fei Fang, Hao Tang, Xiao-Xiao Xia, Qun Xie, Deng-Fu Yao, Wen-Li Sai and Min Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation No. 32470985 Nantong Science and Technology Programs No. MS2024051 Nantong Control of Infectious Diseases No. NTCRB2025016 Nantong Health Commission of China No. QN2025064
Corresponding Author	Min Yao, PhD, Postdoc, Professor, Vice Director, Department of Immunology, Medical School of Nantong University, Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. erbei@ntu.edu.cn
Key Words	Metabolic dysfunction-associated fatty liver disease; Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes; Hepatocellular carcinoma; Mitochondrial damage; Single-cell sequencing
Core Tip	Hepatocyte cyclic guanosine monophosphate-adenosine monophosphate synthase, as a DNA sensor, recognizes damaged mitochondrial DNA with aberrant lipid metabolism to activate stimulator of interferon genes to trigger the expressions of inflammatory factors, such as type-I interferon, which might be closely related to metabolic dysfunction-associated fatty liver disease (MAFLD) progression. However, the molecular mechanisms underlying MAFLD malignancy are still unclear. In this study, the activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway was systematically evaluated in a lipid accumulation model, and the pathogenesis of MAFLD was clarified by evaluating the interactions among hepatocyte injury, inflammatory factors, and immune cells in hepatocarcinogenesis.
Citation	Zhou MY, Fang RF, Tang H, Xia XX, Xie Q, Yao DF, Sai WL, Yao M. Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction. World J Hepatol 2026; In press

Received	2026-03-24 09:26
Peer-Review Started	2026-03-24 09:26
First Decision by Editorial Office Director	2026-04-03 10:06
Return for Revision	2026-04-06 06:29
Revised	2026-04-14 06:08
Publication Fee Transferred	2026-04-15 08:22
Second Decision by Editor	2026-06-01 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-01 09:30
Articles in Press	2026-06-01 09:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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