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Articles in Press
6/4/2026 6:58:17 AM | Browse: 1 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Single-cell and bulk transcriptomics with machine learning decode B cell hub genes and diagnostic biomarkers in anal fistula
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting-Ting Li, Jia-Nan Li, Han-Wen Yang, Xin-Yu Dou, Li Jiang, Li-Xia Lai, Qiang Yu, Xiao-Yu Chen, Yue Wang, Xue-Cheng Zhang, Huang-Fu Ma and Xin-Bo Song |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Elite Medical Professionals Initiative of the China-Japan Friendship Hospital |
ZRJY2025-QM11 |
| National High Level Hospital Clinical Research Funding |
2023-NHLHCRF-YYPPLC-ZR-03 |
| National High Level Hospital Clinical Research Funding |
2025-NHLHCRF-DLYJ-PY-08 |
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| Corresponding Author |
Jia-Nan Li, Department of Proctology, China-Japan Friendship Hospital, No. 2 Yingyuan Garden East Street, Chaoyang District, Beijing 100029, China. wuqu3@163.com |
| Key Words |
Anal fistula; Single-cell RNA sequencing; Bulk RNA sequencing; Machine learning; Immune microenvironment |
| Core Tip |
This study is the first to combine single-cell RNA sequencing (RNA-seq) with bulk RNA-seq and machine learning to systematically characterize B-cell-associated immune networks in anal fistula (AF). Three hub genes, LINC-PINT, LRBA, and SYK, were identified as central signaling nodes linking inflammatory amplification, angiogenesis, and fibrosis within the AF microenvironment. A predictive model incorporating these genes achieved robust diagnostic accuracy, offering promising biomarker candidates for precision diagnosis and targeted therapeutic intervention in AF. |
| Citation |
Li TT, Li JN, Yang HW, Dou XY, Jiang L, Lai LX, Yu Q, Chen XY, Wang Y, Zhang XC, Ma HF, Song XB. Single-cell and bulk transcriptomics with machine learning decode B cell hub genes and diagnostic biomarkers in anal fistula. World J Gastroenterol 2026; In press
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| PDF |
121425-in-press.pdf
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Received |
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2026-03-25 03:00 |
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Peer-Review Started |
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2026-03-25 03:01 |
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First Decision by Editorial Office Director |
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2026-04-10 10:22 |
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Return for Revision |
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2026-04-10 10:22 |
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Revised |
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2026-05-06 03:39 |
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Publication Fee Transferred |
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2026-05-10 07:35 |
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Second Decision by Editor |
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2026-06-04 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-04 06:58 |
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Articles in Press |
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2026-06-04 06:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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