| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Precision management of gastrointestinal tumor-associated osteoporosis driven by cutting-edge technologies: Current status, challenges, and future prospects
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Peng Wang, Jin-Ke Sun, Dong Li, Zhen Shi, Peng-Yu Lu, Dong-Fang Jin, Sheng-Fan Huang, Yu-Hua Ruan, Wen-Ting Li, Meng-Di Shi, Zhan-Hao Ma, Zi-Hao Wang, Li-Yuan Hu, Meng-En Xue, Chang-Jiang Zhang and Zhi-Peng Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key scientific research projects of colleges and universities in Henan Province |
26A320038 |
| Henan province medical science and technology research plan project (joint construction) |
LHGJ20250403; LHGJ20220566; LHGJ20240365 |
| Key Research and Development Program of Henan Province |
231111311000 |
| Medical Education Research Project in Henan Province |
WJLX2023079 |
|
| Corresponding Author |
Zhi-Peng Li, MD, PhD, Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No.3 Kangfuqian Street, Erqi District, Zhengzhou 450052, Henan Province, China. lzpzhonghong@126.com |
| Key Words |
Artificial intelligence; Bone-targeted drug delivery; Gastrointestinal tumor-associated osteoporosis; Gut-bone axis; Microbiome; Multidisciplinary management; Multi-omics; Nanomedicine; Precision medicine; Risk stratification |
| Core Tip |
Gastrointestinal tumor-associated osteoporosis (GTO) is an underrecognized complication that compromises quality of life, treatment adherence, and long-term prognosis. This review highlights how artificial intelligence (AI), bone-targeted nanodelivery, and multiomics are reshaping GTO management from empirical intervention to precision medicine. AI enables opportunistic screening and risk stratification, nanotechnology improves targeted bone protection, and multiomics reveals mechanisms across the tumor-bone-gut axis. The article also addresses key translational barriers, including limited model generalizability, nanomedicine safety, data standardization, and multidisciplinary coordination, and outlines future directions for integrated precision management. |
| Citation |
Wang P, Sun JK, Li D, Shi Z, Lu PY, Jin DF, Huang SF, Ruan YH, Li WT, Shi MD, Ma ZH, Wang ZH, Hu LY, Xue ME, Zhang CJ, Li ZP. Precision management of gastrointestinal tumor-associated osteoporosis driven by cutting-edge technologies: Current status, challenges, and future prospects. World J Methodol 2026; In press |
