Publication Name	World Journal of Cardiology
Manuscript ID	121472
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Preventing anthracycline-induced cardiotoxicity with ivabradine: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Rohab Sohail, Ridda Khattak, Haider Hussain Shah, Zaraq Khan, Shafaq Jawed, Asad Ullah Wasim, Bisma Akram, Rohan Patel, Simran Patel, Madihah Alam, Shahryar Chaudhry, Samar Mehdi, Vyom Patel and Manjeet Singh
Funding Agency and Grant Number
Corresponding Author	Rohab Sohail, MD, Department of Internal Medicine, Bayhealth Medical Center, 640 South State Street, Dover, DE 19904, United States. rohabsohail98@gmail.com
Key Words	Ivabradine; Anthracycline-induced cardiotoxicity; Malignancy; Left ventricular ejection fraction; Global longitudinal strain; Blood pressure; Troponin
Core Tip	Anthracyclines-induced chemotherapy is associated with a risk of cardiotoxicity, often manifesting as reductions in left ventricular ejection fraction and subclinical myocardial injury. In this meta-analysis of randomized studies, ivabradine did not demonstrate a significant effect in preserving left ventricular ejection fraction or improving cardiac biomarkers, including troponin and NT-proBNP, nor did it significantly reduce global longitudinal strain deterioration. These findings suggest that while ivabradine is well tolerated and does not adversely affect blood pressure, current evidence does not support its routine use for the prevention of anthracycline-induced cardiotoxicity. Larger randomized trials are needed to clarify its potential cardioprotective role.
Citation	Sohail R, Khattak R, Shah HH, Khan Z, Jawed S, Wasim AU, Akram B, Patel R, Patel S, Alam M, Chaudhry S, Mehdi S, Patel V, Singh M. Preventing anthracycline-induced cardiotoxicity with ivabradine: A systematic review and meta-analysis. World J Cardiol 2026; In press

Received	2026-03-25 00:42
Peer-Review Started	2026-03-25 03:53
First Decision by Editorial Office Director	2026-04-08 08:37
Return for Revision	2026-04-08 08:37
Revised	2026-04-20 20:56
Publication Fee Transferred	2026-05-09 00:52
Second Decision by Editor	2026-05-28 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-28 11:17
Articles in Press	2026-05-28 11:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com