Publication Name	World Journal of Methodology
Manuscript ID	121475
DOI	10.5662/wjm.121475
Country	United States

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Pharmacology and cardiometabolic impacts of the oral small-molecule glucagon-like peptide-1 receptor agonist orforglipron
Manuscript Source	Invited Manuscript
All Author List	Kevan English and Kritikka Ajit Kumar
Funding Agency and Grant Number
Corresponding Author	Kevan English, MD, Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Emile Street, Omaha, NE 68198, United States. keenglish@unmc.edu
Key Words	Orforglipron; Obesity; Diabetes; Cardiovascular disease; Glucagon-like peptide-1; Hyperlipidemia; Cardiometabolic health; Pharmacology; Inflammation
Core Tip	Obesity and type 2 diabetes mellitus are drivers for the development of atherosclerotic cardiovascular disease. Injectable glucagon-like peptide-1 receptor agonists have revolutionized the treatment of these two interrelated disease entities, which have also shown beneficial impacts on other metabolic properties, including blood pressure and cholesterol levels. However, long-term adherence remains a concern due to the injection burden. Orforglipron is a once-daily oral small-molecule that provides beneficial effects on several cardiometabolic properties. It offers convenience by eliminating the need for weekly injections and refrigeration. Orforglipron may serve as a suitable alternative for the treatment of type 2 diabetes mellitus and obesity.
Citation	English K, Kumar KA. Pharmacology and cardiometabolic impacts of the oral small-molecule glucagon-like peptide-1 receptor agonist orforglipron. World J Methodol 2026; In press DOI: https://doi.org/10.5662/wjm.121475
PDF	121475-in-press.pdf

Received	2026-03-26 03:45
Peer-Review Started	2026-03-26 03:45
First Decision by Editorial Office Director	2026-05-21 07:33
Return for Revision	2026-05-21 07:33
Revised	2026-05-31 17:25
Publication Fee Transferred
Second Decision by Editor	2026-06-18 02:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-18 06:41
Articles in Press	2026-06-18 06:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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