Publication Name	World Journal of Gastroenterology
Manuscript ID	121477
DOI	10.3748/wjg.121477
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Study on the adhesive effect of deoxyshikonin on Helicobacter pylori
Manuscript Source	Unsolicited Manuscript
All Author List	Guang-Fu Pang, Jia-Yin Xu, Ai-Xing Guan, Shi-Xian Yang, Kwanjit Duangsonk, Yan-Qiang Huang, Qi-Hai Zhou and Wen-Ting Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Guangxi Science and Technology Major Project AA23073012 National Natural Science Foundation of China 32360035, 32060018 Guangxi Natural Science Foundation 2025GXNSFHA069251
Corresponding Author	Wen-Ting Zhou, Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. wenting_z@cmu.ac.th
Key Words	Helicobacter pylori; Deoxyshikonin; Urease; Adhesion; Mechanism
Core Tip	Deoxyshikonin exerted dose-responsive anti-adhesion activity against Helicobacter pylori in gastric epithelial cell models. Using an integrated approach combining drug affinity-responsive target stability-mass spectrometry, molecular docking, reverse transcription-quantitative polymerase chain reaction, western blotting, surface plasmon resonance, and urease activity assays, this study identifies urease, particularly UreB, as a key molecular target of deoxyshikonin. The findings further suggest that interference with urease is accompanied by concomitant changes in SabA and BabA expression; however, the precise regulatory mechanism underlying this coordinated response requires further investigation.
Citation	Pang GF, Xu JY, Guan AX, Yang SX, Duangsonk K, Huang YQ, Zhou QH, Zhou WT. Study on the adhesive effect of deoxyshikonin on Helicobacter pylori. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121477
PDF	121477-in-press.pdf

Received	2026-04-14 09:52
Peer-Review Started	2026-04-14 09:52
First Decision by Editorial Office Director	2026-04-29 08:55
Return for Revision	2026-04-29 08:55
Revised	2026-05-11 09:40
Publication Fee Transferred	2026-05-13 03:40
Second Decision by Editor	2026-06-26 02:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-26 06:12
Articles in Press	2026-06-26 06:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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