Publication Name	World Journal of Hepatology
Manuscript ID	121491
DOI	10.4254/wjh.121491
Country	Slovakia

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Second-line treatment of primary biliary cholangitis: To whom, what molecule, and when
Manuscript Source	Invited Manuscript
All Author List	Sylvia Drazilova, Peter Jarcuska, Tomas Koky, Martin Harhovsky, Slavomira Komarova, Jan Vasil and Martin Janicko
Funding Agency and Grant Number
Corresponding Author	Peter Jarcuska, MD, PhD, Professor, 2nd Department of Internal Medicine, PJ Safarik University, Faculty of Medicine and L Pasteur University Hospital, Trieda SNP 1, Kosice 04011, Slovakia. peter.jarcuska@upjs.sk
Key Words	Primary biliary cholangitis; Ursodeoxycholic acid; Second-line treatment; Elafibranor; Seladelpar; Therapeutic response
Core Tip	Primary biliary cholangitis (PBC) is a disease with increasing prevalence, particularly in developed countries. First-line treatment of choice is ursodeoxycholic acid (UDCA), but only about two-thirds of patients achieve biochemical response. UDCA nonresponders have a higher risk of liver cirrhosis decompensation and poorer transplant-free survival. These patients should be considered for second-line therapy. This review provides a comprehensive overview of second-line treatment indications, selection of the most appropriate medication, timing of therapy initiation, benefits, and adverse effects of therapy, as well as the administration of second-line treatment in specific groups of PBC patients.
Citation	Drazilova S, Jarcuska P, Koky T, Harhovsky M, Komarova S, Vasil J, Janicko M. Second-line treatment of primary biliary cholangitis: To whom, what molecule, and when. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.121491
PDF	121491-in-press.pdf

Received	2026-03-26 03:45
Peer-Review Started	2026-03-26 03:45
First Decision by Editorial Office Director	2026-06-10 05:46
Return for Revision	2026-06-10 05:46
Revised	2026-06-23 07:59
Publication Fee Transferred
Second Decision by Editor	2026-07-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-09 08:36
Articles in Press	2026-07-09 08:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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