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Articles in Press
6/18/2026 8:01:03 AM | Browse: 8 | Download: 1
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Tn antigen-driven downregulation of podoplanin promotes colorectal cancer invasion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Wen Fan, Xin-Zhe Wu, Zi-Wei Liu, Qi Lin, Jia-Xin Du, Yan-Tao Tian, Xi-Chen Dong and Dong-Kui Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High Level Hospital Clinical Research Funding |
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| National Natural Science Foundation of China |
No. 82372989 |
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| Corresponding Author |
Dong-Kui Xu, Chief Physician, MD, Professor, Department of Very Important Person, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. 13691583382@163.com |
| Key Words |
Colorectal cancer; O-glycosylation; Podoplanin; T-synthase; C1GALT1 |
| Core Tip |
This study is the first to report that the tumor-suppressive function of the key glycoprotein podoplanin (PDPN) depends strictly on its intact O-glycosylation. When T-synthase deficiency leads to Tn antigen exposure, abnormal PDPN O-glycosylation occurs, resulting in decreased protein stability and functional loss, thereby abolishing the inhibitory effects of PDPN on cell proliferation and migration. These findings provide a new theoretical foundation for the use of glycosylation-dependent PDPN as a prognostic biomarker and targeted therapeutic strategy. |
| Citation |
Fan LW, Wu XZ, Liu ZW, Lin Q, Du JX, Tian YT, Dong XC, Xu DK. Tn antigen-driven downregulation of podoplanin promotes colorectal cancer invasion. World J Gastroenterol 2026; In press
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| PDF |
121494-in-press.pdf
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Received |
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2026-03-27 02:54 |
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Peer-Review Started |
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2026-03-27 02:55 |
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First Decision by Editorial Office Director |
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2026-04-23 09:53 |
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Return for Revision |
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2026-04-23 09:53 |
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Revised |
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2026-05-09 06:42 |
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Publication Fee Transferred |
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2026-05-12 08:19 |
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Second Decision by Editor |
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2026-06-18 02:31 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-18 08:01 |
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Articles in Press |
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2026-06-18 08:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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