Publication Name	World Journal of Gastroenterology
Manuscript ID	121501
DOI	10.3748/wjg.121501
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Ting Peng, Fei-Lan Yang, Shi-Fang Peng and Lei Fu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82570747 Provincial Natural Science Foundation of Hunan Province No. 2022JJ30954 Provincial Natural Science Foundation of Hunan Province No. 2025JJ50599
Corresponding Author	Lei Fu, PhD, Professor, Department of Infectious Diseases, Xiangya Hospital Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. fulei92@126.com
Key Words	Immune checkpoint inhibitors; Liver injury; Predictive model; T cell subpopulation; Complement; Immune-mediated hepatitis
Core Tip	This retrospective study of 544 cancer patients receiving immune checkpoint inhibitors identifies baseline peripheral cluster of differentiation (CD) 3+ CD8+ T cell counts as a novel independent predictor of immune-mediated hepatitis. Integrating this immune parameter with alanine transaminase and complement 4, the authors constructed a nomogram that achieved good discriminatory performance (area under the curve 0.81 in training and 0.80 in validation). This model provides a clinically accessible tool for pre-treatment risk stratification.
Citation	Peng WT, Yang FL, Peng SF, Fu L. Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121501
PDF	121501-in-press.pdf

Received	2026-03-26 02:03
Peer-Review Started	2026-03-26 02:04
First Decision by Editorial Office Director	2026-04-03 10:29
Return for Revision	2026-04-03 10:29
Revised	2026-04-26 18:00
Publication Fee Transferred	2026-04-30 08:51
Second Decision by Editor	2026-06-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 08:15
Articles in Press	2026-06-09 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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