Publication Name	World Journal of Experimental Medicine
Manuscript ID	121518
DOI	10.5493/wjem.121518
Country	India

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates
Manuscript Source	Invited Manuscript
All Author List	Pooja Jayaraman Thirunavukkarasu, Arunagiri Gunasekar, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Viji Devanand, Sanjeevi Bharadwaj and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Bone-specific alkaline phosphatase; Osteoblast; Wnt/β-catenin; Skeletal metabolism; Bone formation
Core Tip	Bone-specific alkaline phosphatase (BSAP) is a good indicator of osteoblastic bone formation, released by osteoblasts as the matrix matures and becomes mineralized. In contrast to imaging, BSAP reflects metabolic activity, increasing early with anabolic therapies and helping to differentiate bone disorders, including Paget’s disease, hypophosphatasia and chronic kidney disease-related bone disease. However, due to the difficulties in standardization and in having norm values, BSAP’s combination with imaging and artificial intelligence models holds the promise of a more accurate and personalized approach to skeletal health.
Citation	Thirunavukkarasu PJ, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Devanand V, Bharadwaj S, Jeyaraman M. Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.121518
PDF	121518-in-press.pdf

Received	2026-03-26 00:50
Peer-Review Started	2026-03-26 01:11
First Decision by Editorial Office Director	2026-04-21 10:03
Return for Revision	2026-04-21 10:03
Revised	2026-05-26 17:39
Publication Fee Transferred
Second Decision by Editor	2026-06-17 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-17 03:01
Articles in Press	2026-06-17 03:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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