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Articles in Press
9/21/2026 9:11:05 AM | Browse: 6 | Download: 0
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Yu Zhu, Meng Yuan, Xiao-Chang Wen, Chen-Chen Tian, Yue-Hua Han, Chen Zheng, Yun-Tao Wu, Qun Xia and Yue Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81273520 |
| Tianjin Key Medical Discipline Construction Project (Orthopedics) |
No. TJYXZDXK-3-005A |
| Great Program of the Science Foundation of Tianjin |
No. 18JCZDJC33200 |
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| Corresponding Author |
Yue Wang, PhD, Professor, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyang Lake Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China. wangyue6806@tjutcm.edu.cn |
| Key Words |
Osthole; Bone; Estrogen receptor; Phosphoinositide 3-kinase/protein kinase B; Mitogen-activated protein kinase kinase/extracellular signal-regulated kinase; Wnt/β-catenin |
| Core Tip |
This study elucidates that osthole, a natural coumarin compound, exerts osteoprotective effects through a novel multi-target mechanism involving simultaneous activation of estrogen receptor, phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase kinase/extracellular signal-regulated kinase, and Wnt/β-catenin signaling pathways in osteoblasts. By directly promoting osteoblast function and indirectly inhibiting osteoclast differentiation via osteoprotegerin/receptor activator of nuclear factor-κB ligand modulation, osthole emerges as a promising natural therapeutic candidate for osteoporosis. |
| Citation |
Zhu TY, Yuan M, Wen XC, Tian CC, Han YH, Zheng C, Wu YT, Xia Q, Wang Y. Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways. World J Orthop 2026; In press
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Received |
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2026-03-27 02:57 |
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Peer-Review Started |
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2026-03-27 02:57 |
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First Decision by Editorial Office Director |
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2026-04-08 08:44 |
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Return for Revision |
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2026-04-08 08:44 |
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Revised |
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2026-04-27 11:15 |
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Publication Fee Transferred |
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2026-07-02 15:16 |
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Second Decision by Editor |
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2026-09-21 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-21 09:11 |
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Articles in Press |
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2026-09-21 09:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
