Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	121535
DOI	10.4291/wjgp.121535
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Araj Naveed Siddiqui, Rabia Hafsa, Vikash Kumar Karmani, Zainab Rehan and Rishi Chowdhary
Funding Agency and Grant Number
Corresponding Author	Rishi Chowdhary, MD, Department of Medicine, MetroHealth Medical Center, Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA., Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. rxc822@case.edu, Cleveland, 44109, United States. rxc822@case.edu
Key Words	Cronkhite-Canada syndrome; Gastrointestinal polyposis; Pathogenesis; Diagnosis; Therapies
Core Tip	Cronkhite-Canada syndrome is a rare, non-hereditary gastrointestinal (GI) polyposis disorder with multisystem involvement and significant diagnostic challenges due to its overlap with more common GI diseases. This review provides a comprehensive synthesis of current evidence, highlighting emerging insights into its multifactorial pathogenesis, including immune dysregulation, microbiome alterations, and potential infectious triggers. It also emphasizes the evolving role of immunosuppressive and biologic therapies alongside nutritional support. By integrating clinical features, diagnostic strategies, and therapeutic approaches, this article proposes a structured framework to improve early recognition, guide management, and reduce long-term complications, including malignancy.
Citation	Siddiqui AN, Hafsa R, Karmani VK, Rehan Z, Chowdhary R. Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies. World J Gastrointest Pathophysiol 2026; In press DOI: https://doi.org/10.4291/wjgp.121535
PDF	121535-in-press.pdf

Received	2026-03-27 03:38
Peer-Review Started	2026-03-27 03:38
First Decision by Editorial Office Director	2026-05-14 02:14
Return for Revision	2026-05-14 02:14
Revised	2026-05-25 20:22
Publication Fee Transferred
Second Decision by Editor	2026-06-25 02:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-25 07:54
Articles in Press	2026-06-25 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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