Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121562
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinicopathological features and prognosis of gastric adenocarcinoma with enteroblastic differentiation
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Lin Wen, Hu Ren, Peng-Hui Niu, He Fei, Ze-Feng Li and Dong-Bing Zhao
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Hope Run Special Fund of Cancer Foundation of China LC2022L03
Corresponding Author	Dong-Bing Zhao, Chief Physician, Professor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing 100021, China. dbzhao@cicams.ac.cn
Key Words	Gastric adenocarcinoma with enteroblastic differentiation; Gastric adenocarcinoma; Prognosis; Overall survival; Progression-free survival
Core Tip	Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare subtype of gastric cancer with distinct clinicopathological characteristics. In this retrospective study, GAED was associated with unique pathological features, a higher risk of recurrence or metastasis, and significantly poorer survival than conventional gastric adenocarcinoma. Notably, its adverse prognosis persisted despite lower rates of some traditional invasive pathological features. These findings suggest that GAED may represent a biologically distinct and clinically aggressive entity that requires closer follow-up and more individualized treatment strategies.
Citation	Wen ZL, Ren H, Niu PH, Fei H, Li ZF, Zhao DB. Clinicopathological features and prognosis of gastric adenocarcinoma with enteroblastic differentiation. World J Gastrointest Oncol 2026; In press

Received	2026-03-27 02:07
Peer-Review Started	2026-03-27 02:07
First Decision by Editorial Office Director	2026-04-10 10:25
Return for Revision	2026-04-11 08:26
Revised	2026-04-17 03:13
Publication Fee Transferred	2026-04-19 04:30
Second Decision by Editor	2026-05-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 09:47
Articles in Press	2026-05-25 09:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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