Publication Name	World Journal of Diabetes
Manuscript ID	121563
DOI	10.4239/wjd.121563
Country	China

Category	Emergency Medicine
Manuscript Type	Randomized Controlled Trial
Article Title	Non-invasive haemodynamic monitoring to individualise fluid resuscitation in adult diabetic ketoacidosis: A randomized controlled pilot trial
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Bo, Hao-Jie Li, Zhuan-Zhuan Han, Li-Jun Tian and Yi-Fei Chen
Funding Agency and Grant Number
Corresponding Author	Yi-Fei Chen, MD, Department of Emergency Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou 225012, Jiangsu Province, China. 090484@yzu.edu.cn
Key Words	Diabetic ketoacidosis; Fluid resuscitation; Non-invasive haemodynamic monitoring; Doppler cardiac output monitoring; Inflammation; Fever
Core Tip	Diabetic ketoacidosis requires urgent fluid resuscitation, yet standard protocols only adopt static volume assessment. This Chinese emergency department mixed-methods study develops a non-invasive doppler strategy combining ultrasonic cardiac output monitoring and passive leg raising for personalised adult diabetic ketoacidosis rehydration. Compared with guideline routine care, it safely lowers 72-hour net fluid balance and hospital stays without harming metabolic or renal recovery. Feasible at bedside, it reduces iatrogenic fluid overload and lessens resource pressure in under-resourced emergency settings without invasive monitors.
Citation	Bo Y, Li HJ, Han ZZ, Tian LJ, Chen YF. Non-invasive haemodynamic monitoring to individualise fluid resuscitation in adult diabetic ketoacidosis: A randomized controlled pilot trial. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.121563
PDF	121563-in-press.pdf

Received	2026-03-27 01:28
Peer-Review Started	2026-03-29 23:57
First Decision by Editorial Office Director	2026-05-27 01:14
Return for Revision	2026-05-27 01:14
Revised	2026-06-09 19:09
Publication Fee Transferred	2026-06-14 09:57
Second Decision by Editor	2026-06-25 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 03:40
Articles in Press	2026-07-02 03:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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