Publication Name	World Journal of Transplantation
Manuscript ID	121567
Country	United States

Category	Anesthesiology
Manuscript Type	Observational Study
Article Title	Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study
Manuscript Source	Invited Manuscript
All Author List	Elizabeth A Wilson, Ammar Rashied, Jamie R Privratsky, Mara Serbanescu, Andrew S Barbas, Kirsten M Williams and Craig M Coopersmith
Funding Agency and Grant Number	Funding Agency Grant Number the Robert W Woodruff Health Science Center and the National Center for Advancing Translational Sciences of the National Institutes of Health under Award UL1TR002378 International Liver Transplantation Society Vanguard Award the National Institutes of Health held by CMC 5R35GM148217-04
Corresponding Author	Elizabeth A Wilson, Assistant Professor, MD, Principal Investigator, Department of Anesthesiology, Duke University School of Medicine, 2301 Erwin Road, Durham, NC 27707, United States. elizabeth.a.wilson@duke.edu
Key Words	Early allograft dysfunction; Ischemia reperfusion injury; Oxidative stress; Biomarkers; Liver transplantation
Core Tip	Early allograft dysfunction (EAD) remains common in liver transplantation, affecting roughly 20%-25% of recipients of allografts preserved via static cold storage, the traditional mode of organ preservation. Dynamic changes in serum cytokine and transcription factor levels - lower baseline interleukin-6, rising interferon-gamma-induced protein 10 peri-implantation, and elevated post-implantation hypoxia inducible factor-1 alpha are associated with EAD, suggesting potential early biomarkers. After validation in a larger study, peri-implantation biomarker profiling may help identify high-risk allografts early, potentially guiding management.
Citation	Wilson EA, Rashied A, Privratsky JR, Serbanescu M, Barbas AS, Williams KM, Coopersmith CM. Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study. World J Transplant 2026; In press

Received	2026-03-27 03:22
Peer-Review Started	2026-03-27 03:24
First Decision by Editorial Office Director	2026-04-08 08:46
Return for Revision	2026-04-08 08:46
Revised	2026-04-20 03:05
Publication Fee Transferred
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 10:52
Articles in Press	2026-05-08 10:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	Early allograft dysfunction (EAD) remains common in liver transplantation, affecting roughly 20%-25% of recipients of allografts preserved via static cold storage, the traditional mode of organ preservation. Dynamic changes in serum cytokine and transcription factor levels - lower baseline interleukin-6, rising interferon-gamma-induced protein 10 peri-implantation, and elevated post-implantation hypoxia inducible factor-1 alpha are associated with EAD, suggesting potential early biomarkers. After validation in a larger study, peri-implantation biomarker profiling may help identify high-risk allografts early, potentially guiding management.
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