Publication Name	World Journal of Gastroenterology
Manuscript ID	121570
DOI	10.3748/wjg.121570
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Cadherin-17: A potential biomarker for early detection in pancreatic adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	William C Cho, Wing S Yu, Tsz C Hon, Elaine T Y Cheung, Xiao Q Wang, Dennis A Wong, Cesar S C Wong, Wah Cheuk and John M Luk
Funding Agency and Grant Number
Corresponding Author	William C Cho, PhD, Senior Scientist, Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR , China. chocs@ha.org.hk
Key Words	Biomarker; Cadherin-17; Carbohydrate antigen 19-9; Early detection; Pancreatic adenocarcinoma; Prognosis
Core Tip	In this pilot study, cadherin-17 (CDH17) was markedly upregulated in pancreatic adenocarcinoma tissue, and its soluble form in plasma distinguished early-stage patients from healthy controls with 86% sensitivity and specificity. These findings point to the biomarker panel consisting of CDH17 and carbohydrate antigen 19-9 offers a possible strategy to address the pressing need for both earlier detection and monitoring disease burden in this malignancy.
Citation	Cho WC, Yu WS, Hon TC, Cheung ET, Wang XQ, Wong DA, Wong CS, Cheuk W, Luk JM. Cadherin-17: A potential biomarker for early detection in pancreatic adenocarcinoma. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121570
PDF	121570-in-press.pdf

Received	2026-03-27 02:06
Peer-Review Started	2026-03-27 02:07
First Decision by Editorial Office Director	2026-04-10 10:26
Return for Revision	2026-04-10 10:26
Revised	2026-04-18 13:52
Publication Fee Transferred
Second Decision by Editor	2026-06-26 02:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-26 06:07
Articles in Press	2026-06-26 06:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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