Publication Name	World Journal of Gastroenterology
Manuscript ID	121572
DOI	10.3748/wjg.121572
Country	Czech Republic

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gluten-free diet reduces severity of dextran sulfate sodium-induced colitis in BALB/c mice
Manuscript Source	Unsolicited Manuscript
All Author List	David Funda, Barbora Drabonova, Jaroslav Golias, Tereza Tejklova, Radka Cisarova, Jitka Bartosova and Pavel Drastich
Funding Agency and Grant Number	Funding Agency Grant Number AZV Grant from the Ministry of Health of the Czech Republic No. NU22-06-00269
Corresponding Author	David Funda, MD, PhD, Senior Scientist, Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, Prague 140 00, Czech Republic. funda@biomed.cas.cz
Key Words	Gluten-free diet; Inflammatory bowel disease; Colitis; Intestinal inflammation; Nutrition
Core Tip	A gluten-free diet (GFD) markedly attenuated dextran sulfate sodium-induced colitis in BALB/c mice, reducing clinical and histological disease severity. Gluten withdrawal decreased colonic lymphocyte antigen 6C+ monocyte infiltration and promoted anti-inflammatory immune responses, including increased proportions of forkhead box P3+ regulatory T cells and interleukin-10+ T helper cells, as well as γδ T cells. These findings highlight a previously underappreciated role of dietary gluten in intestinal inflammation and support a GFD as a potential non-pharmacological strategy for modulating immune responses in inflammatory bowel disease.
Citation	Funda D, Drabonova B, Golias J, Tejklova T, Cisarova R, Bartosova J, Drastich P. Gluten-free diet reduces severity of dextran sulfate sodium-induced colitis in BALB/c mice. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121572
PDF	121572-in-press.pdf

Received	2026-04-13 01:23
Peer-Review Started	2026-04-13 01:24
First Decision by Editorial Office Director	2026-04-29 10:13
Return for Revision	2026-04-29 10:13
Revised	2026-06-05 21:58
Publication Fee Transferred	2026-06-16 10:13
Second Decision by Editor	2026-09-16 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-16 09:34
Articles in Press	2026-09-16 09:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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