Publication Name	World Journal of Cardiology
Manuscript ID	121611
DOI	10.4330/wjc.121611
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Dose-dependent efficacy of olezarsen in high-risk hypertriglyceridemia: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Vyom Patel, Rohab Sohail, Madihah Alam, Shahryar Chaudhry, Samar Mehdi, Simran Patel, Rohan Patel, Ridda Khattak, Zaraq Khan and Manan Patel
Funding Agency and Grant Number
Corresponding Author	Vyom Patel, MD, Principal Investigator, Department of Internal Medicine, Indiana University School of Medicine, INDIANA UNIVERSITY SCHOOL OF MEDICINE, Department of Internal Medicine, Indiana University School of Medicine, Southwest Internal Medicine Residency Program, Evansville, Indiana, USA. Electronic address: vyompate@iu.edu, Evansville, IN 47591, United States. vyompate@iu.edu
Key Words	Olezarsen; Dose-dependent effectiveness; Side-effects; Apolipoprotein C-III; Hypertriglyceridemia
Core Tip	This meta-analysis of three randomized controlled trials is the first to directly compare olezarsen 80 mg vs 50 mg in patients with high-risk hypertriglyceridemia. While the 80 mg dose produced a statistically significant incremental reduction in apolipoprotein C-III (apoC-III), no significant differences were observed in triglyceride, non-high-density lipoprotein cholesterol, or safety outcomes. These findings suggest that higher dosing confers limited added benefit beyond apoC-III suppression, though equivalence cannot be established from the available evidence.
Citation	Patel V, Sohail R, Alam M, Chaudhry S, Mehdi S, Patel S, Patel R, Khattak R, Khan Z, Patel M. Dose-dependent efficacy of olezarsen in high-risk hypertriglyceridemia: A meta-analysis. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.121611
PDF	121611-in-press.pdf

Received	2026-03-30 01:58
Peer-Review Started	2026-03-31 03:33
First Decision by Editorial Office Director	2026-04-13 08:31
Return for Revision	2026-04-13 08:31
Revised	2026-05-02 03:14
Publication Fee Transferred	2026-05-11 02:16
Second Decision by Editor	2026-06-16 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-16 09:18
Articles in Press	2026-06-16 09:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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