Publication Name	World Journal of Methodology
Manuscript ID	121613
DOI	10.5662/wjm.121613
Country	India

Category	Ophthalmology
Manuscript Type	Observational Study
Article Title	Retromode imaging for quantitative mapping and phenotypic characterization of subretinal Drusenoid deposits in age-related macular degeneration: A multimodal methodological study
Manuscript Source	Invited Manuscript
All Author List	Ramesh Venkatesh, Prathibha Hande, Vighnesh Shetty, Gaurav Malwe, Deepika Parameswarappa, Vishma Prabhu and Rohit Shetty
Funding Agency and Grant Number
Corresponding Author	Ramesh Venkatesh, Consultant, Department of Ophthalmology, Narayana Nethralaya, 121/C. 1st R block, West of Chord Road, Rajaji Nagar, Bangalore 560010, India. vramesh80@yahoo.com
Key Words	Subretinal drusenoid deposits; Retromode imaging; Age-related macular degeneration; Multimodal imaging; En face imaging
Core Tip	Subretinal drusenoid deposits (SDDs) are an important high-risk phenotype in age-related macular degeneration (AMD), but accurate assessment of disease burden remains challenging with conventional imaging. This study demonstrates that retromode scanning laser ophthalmoscopy enables superior quantitative mapping of SDD extent compared with standard en face modalities and identifies additional subclinical lesions corresponding to early structural abnormalities on optical coherence tomography. Retromode imaging also facilitates phenotypic characterisation of dot-type and ribbon-type SDDs, highlighting its potential role in improved AMD phenotyping, risk stratification, longitudinal monitoring, and future imaging biomarker development.
Citation	Venkatesh R, Hande P, Shetty V, Malwe G, Parameswarappa D, Prabhu V, Shetty R. Retromode imaging for quantitative mapping and phenotypic characterization of subretinal Drusenoid deposits in age-related macular degeneration: A multimodal methodological study. World J Methodol 2026; In press DOI: https://doi.org/10.5662/wjm.121613
PDF	121613-in-press.pdf

Received	2026-04-01 06:50
Peer-Review Started	2026-04-01 06:54
First Decision by Editorial Office Director	2026-05-22 10:22
Return for Revision	2026-05-22 10:22
Revised	2026-05-25 07:20
Publication Fee Transferred
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 09:06
Articles in Press	2026-06-22 09:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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