Publication Name	World Journal of Diabetes
Manuscript ID	121630
DOI	10.4239/wjd.121630
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Postmenopausal high-gonadotropin-releasing hormone environment mediates pancreatic β-cell compensation via the cAMP-PKA-PDX1 pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Juan Dai, Shi-Cong Gao, Peng-Tao Chen, Lu Yang, Chu-Chu Kong, Cui-Ying Ye, Zi-Xuan Xu, Ya-Xin Hu, Cheng-Yong He, Zheng-Hong Zuo and Wei Wang
Funding Agency and Grant Number
Corresponding Author	Wei Wang, Professor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2000 Xiang’an East Road, Xiang’an District, Xiamen 361102, Fujian Province, China. wwang@xah.xmu.edu.cn
Key Words	Gonadotropin-releasing hormone; Gonadotropin-releasing hormone receptor; Pancreatic β-cells; Insulin secretion; Menopause
Core Tip	This study examines the metabolic significance of elevated gonadotropin-releasing hormone (GnRH) in the postmenopausal state. We found that GnRH receptor is preferentially expressed in pancreatic β-cells and that GnRH enhances insulin secretion through the cAMP-PKA-PDX1 signaling pathway. These findings suggest that postmenopausal hypothalamic-pituitary-gonadal axis remodeling may contribute to β-cell compensation and provide a mechanistic link between reproductive endocrine aging and glucose homeostasis.
Citation	Dai XJ, Gao SC, Chen PT, Yang L, Kong CC, Ye CY, Xu ZX, Hu YX, He CY, Zuo ZH, Wang W. Postmenopausal high-gonadotropin-releasing hormone environment mediates pancreatic β-cell compensation via the cAMP-PKA-PDX1 pathway. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.121630
PDF	121630-in-press.pdf

Received	2026-04-07 00:34
Peer-Review Started	2026-04-12 23:53
First Decision by Editorial Office Director	2026-04-28 00:59
Return for Revision	2026-04-28 00:59
Revised	2026-05-14 12:10
Publication Fee Transferred	2026-05-19 08:07
Second Decision by Editor	2026-07-06 07:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-24 08:42
Articles in Press	2026-09-24 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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