Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121634
DOI	10.4251/wjgo.121634
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Proportion of esophageal keratinized area ≥ 30% reduces accuracy of preoperative endoscopic evaluation in early esophageal squamous cell carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Jie zhang, Wu Wen, Fan Li, Jing Yuan, De-Hong Zou, Hai-Peng Shi, Chuan Liang and Ye Yang
Funding Agency and Grant Number
Corresponding Author	Ying-Jie zhang, Department of Digestive Diseases, Chengdu Second People’s Hospital affiliated to West China School of Medicine, Sichuan University, No. 10 Qingyun South Street, Chengdu 610000, Sichuan Province, China. 13890410927@163.com
Key Words	Esophageal keratosis; Early esophageal squamous cell carcinoma; Diagnostic accuracy; Endoscopic assessment; Infiltrate; Keratinized area
Core Tip	Esophageal keratosis in early esophageal squamous cell carcinoma (ESCC) is associated with tumor infiltration and may reflect invasion depth. Preoperative endoscopic assessment based on intraluminal papillary capillary loop morphology in nonkeratinized areas is reliable for most early ESCCs; however, its accuracy may decrease when the keratinized area accounts for ≥ 30% of the lesion. The extent of keratinization may also be related to lesion size, although further studies are needed to confirm these associations.
Citation	Zhang YJ, Wen W, Li F, Yuan J, Zou DH, Shi HP, Liang C, Yang Y. Proportion of esophageal keratinized area ≥ 30% reduces accuracy of preoperative endoscopic evaluation in early esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.121634
PDF	121634-in-press.pdf

Received	2026-04-02 07:19
Peer-Review Started	2026-04-02 07:20
First Decision by Editorial Office Director	2026-06-11 10:05
Return for Revision	2026-06-11 10:05
Revised	2026-06-25 05:04
Publication Fee Transferred	2026-07-28 11:46
Second Decision by Editor	2026-10-09 03:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:29
Articles in Press	2026-10-09 09:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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