Publication Name	World Journal of Translational Medicine
Manuscript ID	121646
DOI	10.5528/wjtm.121646
Country	United States

Category	Respiratory System
Manuscript Type	Minireviews
Article Title	Mortality despite new generation medications for pediatric neuromuscular diseases and how to prevent it
Manuscript Source	Invited Manuscript
All Author List	Maninderpal Kaur and John Bach
Funding Agency and Grant Number
Corresponding Author	Maninderpal Kaur, Assistant Professor, MD, Department of Medicine, Rutgers New Jersey Medical School, University Hospital, 150 Bergen Street, H245, Newark, NJ 07103, United States. mk1786@njms.rutgers.edu
Key Words	Noninvasive ventilation; Noninvasive ventilatory support; Neuromuscular diseases; Mechanical insufflation exsufflation; Spinal muscular atrophy; Muscular dystrophy; Extubation; Decannulation
Core Tip	New gene and RNA-based therapies slow progression of pediatric neuromuscular diseases but do not restore effective cough. When hypoxic episodes are treated with supplemental oxygen instead of noninvasive ventilatory support (NVS) and mechanical insufflation-exsufflation (MIE), CO2 narcosis, intubation, and unnecessary tracheostomy or death often follow. Extubating ventilator-unweanable patients directly to continuous NVS and MIE, rather than pursuing prolonged weaning trials, allows most to return to their prior ventilator-use regimens without tracheostomy. This approach also saves over $500000 per patient annually in nursing and medical costs while preserving quality of life.
Citation	Kaur M, Bach J. Mortality despite new generation medications for pediatric neuromuscular diseases and how to prevent it. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.121646
PDF	121646-in-press.pdf

Received	2026-03-30 07:41
Peer-Review Started	2026-03-30 07:45
First Decision by Editorial Office Director	2026-06-05 08:10
Return for Revision	2026-07-03 19:59
Revised	2026-07-12 13:41
Publication Fee Transferred
Second Decision by Editor	2026-07-28 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:26
Articles in Press	2026-07-28 13:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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