Publication Name	World Journal of Stem Cells
Manuscript ID	121648
DOI	10.4252/wjsc.121648
Country	Japan

Category	Cell & Tissue Engineering
Manuscript Type	Minireviews
Article Title	From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Bo-Lin Zhang, Shinichiro Kobayashi, Lu-Yang Li, Tian-Yang Li, Shinichiro Ogawa, Daisuke Miyamoto, Kayo Hasegawa, Shun Yamaguchi, Tomohiko Adachi, Susumu Eguchi and Kengo Kanetaka
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research C 24K11935 Japan Agency for Medical Research and Development 25ym0126811j0004
Corresponding Author	Shinichiro Kobayashi, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki 852-8501, Japan. skobayashi1980@gmail.com
Key Words	Cell sheet technology; Mesenchymal stem cells; Myoblasts; Regenerative medicine; Inflammatory bowel disease; Crohn’s disease
Core Tip	Crohn’s disease fistulas remain a clinical challenge because current therapies mainly suppress inflammation without restoring the damaged tissue’s architecture. This review highlights cell sheet technology as a scaffold-free regenerative platform with superior cell retention, extracellular matrix preservation, and sustained paracrine activity. While mesenchymal stem cell therapies mainly provide regulatory repair, myoblast cell sheets add intrinsic myogenic potential, enabling reconstruction of the disrupted muscle layer and functional tissue recovery. By shifting the therapeutic goal from inflammation control to structural regeneration, myoblast cell sheets may offer a next-generation strategy for the durable repair of complex Crohn’s disease fistulas.
Citation	Zhang BL, Kobayashi S, Li LY, Li TY, Ogawa S, Miyamoto D, Hasegawa K, Yamaguchi S, Adachi T, Eguchi S, Kanetaka K. From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.121648
PDF	121648-in-press.pdf

Received	2026-03-31 05:57
Peer-Review Started	2026-03-31 06:00
First Decision by Editorial Office Director	2026-04-21 09:16
Return for Revision	2026-04-21 09:16
Revised	2026-05-19 00:49
Publication Fee Transferred
Second Decision by Editor	2026-06-12 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 07:06
Articles in Press	2026-06-15 07:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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