Publication Name	World Journal of Nephrology
Manuscript ID	121652
Country	United Kingdom

Category	Urology & Nephrology
Manuscript Type	Systematic Reviews
Article Title	From kidney to liver: Are sodium–glucose cotransporter-2 inhibitors emerging as metabolic disease modifiers?
Manuscript Source	Invited Manuscript
All Author List	Sydney Mpisa and Jonathan Soldera
Funding Agency and Grant Number
Corresponding Author	Jonathan Soldera, Tutor, Gastroenterology and Acute Medicine, University of South Wales (in association with Learna Ltd.), University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com
Key Words	Hepatocellular carcinoma; Sodium-glucose transporter 2 inhibitors; Metabolic dysfunction-associated steatotic liver disease; Chronic kidney disease; Metabolic disease modification
Core Tip	Sodium-glucose cotransporter-2 inhibitors extend beyond glycaemic control and may modify key pathways of metabolic disease. Evidence from diabetic kidney disease and metabolic dysfunction-associated steatotic liver disease suggests these agents attenuate inflammation and fibrosis, with a potential association with reduced hepatocellular carcinoma incidence. This supports a shift toward integrated, cross-organ metabolic disease modification.
Citation	Mpisa S, Soldera J. From kidney to liver: Are sodium–glucose cotransporter-2 inhibitors emerging as metabolic disease modifiers? World J Nephrol 2026; In press

Received	2026-03-30 07:40
Peer-Review Started	2026-03-30 07:45
First Decision by Editorial Office Director	2026-04-15 09:16
Return for Revision	2026-04-15 09:16
Revised	2026-04-28 03:44
Publication Fee Transferred
Second Decision by Editor	2026-05-21 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-21 08:25
Articles in Press	2026-05-21 08:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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