Publication Name	World Journal of Clinical Cases
Manuscript ID	121660
DOI	10.12998/wjcc.121660
Country	Bangladesh

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Wilson disease in children: Recent update on pathophysiology and management
Manuscript Source	Invited Manuscript
All Author List	Khan Lamia Nahid, Mohammad Rukunuzzaman, Rubaiyat Alam and Fahmida Begum
Funding Agency and Grant Number
Corresponding Author	Khan Lamia Nahid, Associate Professor, Paediatric Gastroenterology and Nutrition, Bangladesh Medical University (BMU), Shahbag, Dhaka 1000, Dhaka, Bangladesh. lamianahid@yahoo.com
Key Words	Wilson disease; pathophysiology; ATP7B; Copper; Penicillamine
Core Tip	Wilson disease (WD) is an autosomal recessive disease caused by mutations in ATP7B gene which has fundamental role in copper metabolism, leading to accumulation of copper in liver and other vital organs. Major functions of ATP7B are incorporation of copper into apoceruloplasmin and the excretion of copper into bile. From simple asymptomatic elevation of liver enzyme to acute liver failure, chronic hepatitis, portal hypertension may be the initial hepatic presentation of this disease. No single test is diagnostic for WD. Initial testing includes ocular slit-lamp examination, 24-hour urinary copper excretion and serum ceruloplasmin. Leipzig scoring system for diagnosis is used widely. Relative exchangeable copper is the new non-invasive biomarker for WD diagnosis with highest sensitivity and specificity. Patients need lifelong chelation therapy until liver transplantation.
Citation	Nahid KL, Rukunuzzaman M, Alam R, Begum F. Wilson disease in children: Recent update on pathophysiology and management. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.121660
PDF	121660-in-press.pdf

Received	2026-03-30 07:27
Peer-Review Started	2026-03-31 07:08
First Decision by Editorial Office Director	2026-04-10 08:10
Return for Revision	2026-04-10 08:10
Revised	2026-05-09 05:06
Publication Fee Transferred
Second Decision by Editor	2026-06-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-11 07:58
Articles in Press	2026-06-11 07:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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