Publication Name	World Journal of Biological Chemistry
Manuscript ID	121664
DOI	10.4331/wjbc.121664
Country	Japan

Category	Oncology
Manuscript Type	Basic Study
Article Title	Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma
Manuscript Source	Invited Manuscript
All Author List	Daiki Imanishi, Hinano Nishikubo, Dongheng Ma, Tomoya Sano, Canfeng Fan, Takashi Sakuma and Masakazu Yashiro
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aid for Scientific Research No. 24K02525
Corresponding Author	Masakazu Yashiro, MD, PhD, Department of Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 5458585, Japan. i21496f@omu.ac.jp
Key Words	Transforming growth factor beta 2; Gastric cancer; Cancer-associated fibroblasts; Tumor microenvironment
Core Tip	The immunohistochemical analysis of gastric carcinoma was performed to clarify the clinical function of transforming growth factor beta 2 (TGFβ2) on the progression of gastric carcinoma. TGFβ2 expression on cancer-associated fibroblasts (CAFs) was significantly correlated with lymph node metastasis and vascular invasion, but not with the T factor. Five-year survival of patients with TGFβ2-high on cancer cells and -low on CAFs was significantly worse in compared to the other group TGFβ2 on cancer cells might stimulates the cancer proliferation and invasion, but not TGFβ2 on CAFs. TGFβ2 high on cancer cells and low on CAF or others might be a promising prognostic factor for patients with GC.
Citation	Imanishi D, Nishikubo H, Ma D, Sano T, Fan C, Sakuma T, Yashiro M. Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma. World J Biol Chem 2026; In press DOI: https://doi.org/10.4331/wjbc.121664
PDF	121664-in-press.pdf

Received	2026-04-01 07:44
Peer-Review Started	2026-04-01 07:45
First Decision by Editorial Office Director	2026-04-17 08:15
Return for Revision	2026-04-17 08:15
Revised	2026-05-11 07:33
Publication Fee Transferred
Second Decision by Editor	2026-06-08 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-08 09:32
Articles in Press	2026-06-08 09:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8454 (online)
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