Publication Name	World Journal of Gastroenterology
Manuscript ID	121683
Country	Argentina

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Skeletal muscle transcriptomics in metabolic dysfunction-associated steatotic liver disease - balancing promise with validation
Manuscript Source	Unsolicited Manuscript
All Author List	María Victoria Delpino
Funding Agency and Grant Number
Corresponding Author	María Victoria Delpino, Instituto de Investigaciones Biomédicas en Retrovirus y Sida, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Paraguay 2155, Buenos Aires C1121ABG, Argentina. mdelpino@ffyb.uba.ar
Key Words	Metabolic dysfunction-associated steatotic liver disease; Exercise-responsive genes; Skeletal muscle; Biomarkers; Muscle-liver crosstalk
Core Tip	Zhang et al identify exercise-responsive skeletal muscle genes that may help explain the metabolic benefits of exercise in metabolic dysfunction-associated steatotic liver disease. Their integrative approach is promising, but these candidate markers require validation in well-designed, multi-center prospective human cohorts with paired liver histology or imaging data, additional human validation and functional studies before they can be considered for clinical use.
Citation	Delpino MV. Letter to the Editor: Skeletal muscle transcriptomics in metabolic dysfunction-associated steatotic liver disease - balancing promise with validation. World J Gastroenterol 2026; In press

Received	2026-03-30 00:46
Peer-Review Started	2026-03-31 07:30
First Decision by Editorial Office Director	2026-04-15 08:45
Return for Revision	2026-04-15 08:45
Revised	2026-04-16 12:39
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 07:54
Articles in Press	2026-05-18 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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