Publication Name	World Journal of Biological Chemistry
Manuscript ID	121685
Country	Egypt

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects
Manuscript Source	Invited Manuscript
All Author List	Doha Mohamed, Asmaa A Ramadan, Hoda B Mabrok and Ibrahim Hamed
Funding Agency and Grant Number
Corresponding Author	Doha Mohamed, PhD, Professor, Department of Nutrition and Food Science, Food Industries and Nutrition Institute, National Research Centre, 33 El Buhouth Street, Ad Doqi, Dokki, Cairo 12622, Al Qāhirah, Egypt. dohaabdomohamed@gmail.com
Key Words	Phytosterols; Lipid metabolism; Cholesterol absorption; Molecular mechanisms; Inflammation; Oxidative stress; Metabolic disorders; Cardiovascular disease; Functional foods
Core Tip	Phytosterols are well-established cholesterol-lowering agents, but emerging evidence highlights their broader biological roles. This review provides a comprehensive synthesis of molecular mechanisms underlying phytosterol action, including modulation of liver X receptors, peroxisome proliferator-activated receptors, and AMP-activated protein kinase signaling, membrane lipid organization, and gut microbiota-bile acid interactions. These integrated pathways contribute to improved lipid and glucose metabolism, reduced inflammation, and enhanced cardiometabolic health, supporting the potential of phytosterols as multifunctional dietary bioactives beyond lipid lowering.
Citation	Mohamed D, Ramadan AA, Mabrok HB, Hamed I. Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects. World J Biol Chem 2026; In press

Received	2026-03-30 07:30
Peer-Review Started	2026-03-31 07:35
First Decision by Editorial Office Director	2026-04-15 09:02
Return for Revision	2026-04-15 09:02
Revised	2026-05-03 18:09
Publication Fee Transferred
Second Decision by Editor	2026-05-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 06:06
Articles in Press	2026-05-25 06:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8454 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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