Publication Name	World Journal of Stem Cells
Manuscript ID	121713
DOI	10.4252/wjsc.121713
Country	China

Category	Cell Biology
Manuscript Type	Review
Article Title	Applying microfluidic techniques for biomaterial and mechanical regulation of mesenchymal stem cells
Manuscript Source	Invited Manuscript
All Author List	Bing-Qi Song, Jing Du and Xiao-Ming Li
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Natural Science Foundation L251086, L248028 National Natural Science Foundation of China 32571560, 82273500
Corresponding Author	Xiao-Ming Li, PhD, Professor, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices of Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100191, China. x.m.li@hotmail.com
Key Words	Microfluidic techniques; Mesenchymal stem cells; Biomaterials; Mechanical stress; Single-cell analysis; Three-dimensional cell culture
Core Tip	This review organizes microfluidic applications for mesenchymal stem cell research into three sequential stages: Cell quality control to acquire pure subpopulations, microenvironment engineering to replicate the physiological microenvironment, and phenotypic monitoring to track real-time responses. These continuous stages consequently link raw cell preparation to functional readout. To accelerate the clinical adoption of stem cell therapies, we propose that integration, intelligence, and scalable manufacturing are crucial directions for microfluidic systems.
Citation	Song BQ, Du J, Li XM. Applying microfluidic techniques for biomaterial and mechanical regulation of mesenchymal stem cells. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.121713
PDF	121713-in-press.pdf

Received	2026-04-01 08:23
Peer-Review Started	2026-04-01 08:24
First Decision by Editorial Office Director	2026-04-23 03:26
Return for Revision	2026-04-23 03:26
Revised	2026-05-07 03:57
Publication Fee Transferred
Second Decision by Editor	2026-06-01 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 08:51
Articles in Press	2026-06-04 08:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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