Publication Name	World Journal of Transplantation
Manuscript ID	121739
Country	United Kingdom

Category	Medicine, Research & Experimental
Manuscript Type	Systematic Reviews
Article Title	Total intravenous anesthesia in kidney transplantation: A narrative review
Manuscript Source	Invited Manuscript
All Author List	Ervandy Rangganata, Juanita Castellanos De Brigard, Apostolos Prionas, Nagy Habib and Vassilios E Papalois
Funding Agency and Grant Number
Corresponding Author	Ervandy Rangganata, Doctorate Student, MD, Department of Surgery and Cancer, Imperial College London, Du Cane Road London W12 0HS, London W12 0HS, London, City of, United Kingdom. e.rangganata24@imperial.ac.uk
Key Words	Kidney transplantation; Total intravenous anesthesia; Propofol; Volatile anesthesia; Sevoflurane; Ischaemia-reperfusion injury; Delayed graft function; Postoperative recovery
Core Tip	This narrative review compares propofol-based total intravenous anaesthesia (TIVA) with volatile anaesthesia in adult kidney transplantation. Across six comparable studies, TIVA delivers haemodynamic stability and graft function equivalent to volatile maintenance, with reproducible advantages in extubation time and postoperative nausea and vomiting—the latter clinically important for reliable early enteral absorption of immunosuppressants. The biomarker signal of reduced tubular stress under propofol from the VAPOR-1 trial has not translated into measurable clinical benefit in low-risk living-donor cohorts. The next critical step is an adequately powered multicentre randomised trial in extended-criteria-donor and donation-after-circulatory-death recipients, with standardised opioid, fluid, and vasopressor protocols.
Citation	Rangganata E, Castellanos De Brigard J, Prionas A, Habib N, Papalois VE. Total intravenous anesthesia in kidney transplantation: A narrative review. World J Transplant 2026; In press

Received	2026-03-31 03:42
Peer-Review Started	2026-03-31 03:44
First Decision by Editorial Office Director	2026-06-11 02:31
Return for Revision	2026-06-11 02:31
Revised	2026-06-30 21:52
Publication Fee Transferred
Second Decision by Editor	2026-07-23 07:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 07:18
Articles in Press	2026-07-27 07:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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