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Articles in Press
8/28/2026 9:13:49 AM | Browse: 5 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Estrogen receptor 1 regulates ovarian cancer cell stemness and ferroptosis through modulation of the canonical RhoA/ROCK signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shun Zhou, Xue Cheng, Jing-Min Zhang, Jie Ji, Zhen-Zhen Ni and Wei Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Talent Construction Fund Research Project of Jiangsu Province Geriatric Hospital |
IR2024101 |
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| Corresponding Author |
Wei Wang, Department of Pathology, Jiangsu Province Official Hospital, Geriatric Hospital of Nanjing Medical University, No. 65 Jiangsu Road, Nanjing 210009, Jiangsu Province, China. path_lucky@126.com |
| Key Words |
Estrogen receptor 1; Ovarian cancer; Cell stemness; Ferroptosis; RhoA/ROCK |
| Core Tip |
This study investigated the effects of estrogen receptor 1 (ESR1) on ovarian cancer. Our findings revealed that ESR1, an overexpressed gene associated with cell stemness and ferroptosis in ovarian cancer, interacts with the Ras homolog (Rho) gene family member A/Rho-associated coiled-coil containing protein kinase signaling pathway. ESR1 knockdown in A2780 cells significantly decreased cell viability and proliferation, while increasing apoptosis. ESR1 silencing also reduced cell stemness (lowered aldehyde dehydrogenase, octamer-binding transcription factor 4, and Nanog) and promoted ferroptosis (increased Fe2+, ferritin heavy chain, and ferritin light chain, and decreased transferrin receptor 1). These inhibitory effects were reversed by treatment with CN03 (a Rho activator), demonstrating that ESR1 regulates ovarian cancer stemness and ferroptosis via the Ras homolog gene family member A/Rho-associated coiled-coil containing protein kinase signaling pathway. |
| Citation |
Zhou S, Cheng X, Zhang JM, Ji J, Ni ZZ, Wang W. Estrogen receptor 1 regulates ovarian cancer cell stemness and ferroptosis through modulation of the canonical RhoA/ROCK signaling pathway. World J Stem Cells 2026; In press
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| PDF |
121744-in-press.pdf
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Received |
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2026-04-01 06:23 |
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Peer-Review Started |
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2026-04-01 06:24 |
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First Decision by Editorial Office Director |
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2026-04-30 07:32 |
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Return for Revision |
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2026-04-30 07:32 |
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Revised |
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2026-05-19 08:46 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-03 02:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-28 09:13 |
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Articles in Press |
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2026-08-28 09:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
